An efficient and selective method for the deprotection of primary alcoholic tert-butyl-dimethylsilyl (TBS) ethers using SnC12'2H20 as catalyst is described. The reaction conditions allow primary alcoholic TBS ethers to be desilylated chemoselectively in the presence of phenolic TBS ethers, secondary and tertiary alcolholic TBS ethers, and the extensively used TBDPS-, acetyl-, benzyloxycarbonyl-, p-toluenesulfonyl- and benzyl protective groups.
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