Formation,Structure and In Vitro Antitumour Activity of a Novel Binuclear Organotin Complex

摘要

A 1:1 reaction of triphenyltin chloride with potassium N-[(3,5-dibromo-2-hydroxyl- phenyl)methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, (HL)SnPh3Ph2SnL [L=2-O-3,5-Br2C6H3CH=NCH(i-Pr)COO], by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O2SnC2N and a trans-O2SnC3 in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antitumor activity of the complex against three human tumour cell lines (HeLa, CoLo205 and MCF-7) was found to be much higher than cis-platin used in clinic.