Synthesis and Antibacterial Activity of New Cephalosporin Compounds

摘要

Five new cephalosporin compounds were designed and synthesized, and the antibacterial activities were evaluated by the standard serial 2-fold agar dilution method in vitro. The results showed that the activities of the compounds Ia and Ib against ESBL E. coli and K. pneumoniae are comparable to those of Cefepime.