A Facile Stereospecific Synthesis of 1, 3-Enynylsulfides via Sonogashira Coupling of （E）-a-Iodovinyl Sulfides with 1-Alkynes

摘要

(E)-α-Iodovinyl sulfides 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol % of Pd(PPh3)4 and 10 mol % of CuI to afford the corresponding 1, 3-enynylsulfides 3 stereospecifically in high yields.