Stereoselective cycloaddition of N-acyliminium cations withα,β-unsaturated ketones and esters

摘要

The cycloaddition of N-acyliminium cations with some deactivated alkenes such asα,β-unsaturate ketones and esters has been investigated.In most cases,the N-acyliminium cations produced from 3-hydroxy-2-arylisoindol-1-ones in the presence of BF_3·OEt_2 could be reacted withα,β-unsaturated ketones and esters to afford stereoselectively the cycloaddition products 6-acylisoindolo[2,1-a] quinolin-11-ones in moderate to high yields.