A simple and convenient method for direct α-chlorination of ketones with ammonium chloride and Oxone

摘要

When ketones were treated with ammonium chloride and Oxone（R） in MeOH at room temperature,a direct α-chlorination of ketones was occurred and a series of the corresponding α-chloroketones were obtained in moderate to good yields after 24 h.In this reaction,ammonium chloride was used as the source of chlorine and Oxone（R） was used as an oxidant.This method was simple,convenient and providing a novel procedure for preparation of α-chloroketones.