Cu(Ⅱ)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone

摘要

A novel method for achieving a copper(II)-catalyzed domino reaction for the construction of 2-aryl quinazolinones,without the addition of any ligand and additive,has been developed.The domino reaction achieved N-(a-substituted)benzylation,benzylic C–H amidation,and C–C(or C–H) bond cleavage.