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Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa

         

摘要

Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E (1 and 2),together with three known analogs.The structures of the new compounds were established by extensive analysis of 1D and 2D NMR spectra,as well as MS data.Their absolute configurations were determined by CD spectra.All compounds showed moderate inhibitory effects on A431,A549,BGC-823,HL-60,HT-29,and MCF-7 cancer cell lines with 1C5o values ranging from 2.1 to 36.3 μM.

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  • 来源
    《中国化学快报(英文版)》 |2017年第5期|927-930|共4页
  • 作者单位

    State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China;

    University of Chinese Academy of Sciences, Beijing 100049, China;

    State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China;

    Department of NMR Technology Services, Public Technical Service Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;

    State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China;

    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China;

    State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China;

    State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China;

    School of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China;

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