A new cytotoxic salannin-class limonoid alkaloid from seeds of Azadirachta indica A.Juss

摘要

A new cytotoxic salannin-class limonoid alkaloid,azadiramide A (1),was isolated from seeds of Azadirachta indica A.Juss.Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation.Compound 1 is a rare salannin-class limonoid alkaloid.To our best knowledge,only two compounds belonging to this type were so far found.It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC5o value of 2.70 ± 0.63 μ mol/L.