By means of immunohistological technique, theexpressions of p53, c-erbB-2, EGFR and ras wereexamined on the adjacent sections of 75 cases of gastriccancer (GC), and their clinicopathological and prognosticsignificance were studied. Results: 1) Overexpressionsof p53 and c-erbB-2 were early and late sign of malignantchange of gastric mucosa, respectively: EGFR and rashad close association with the degree of malignancy ofGC. 2) The expression of ras had positive relationshipwith the expression of EGFR, and negative relationshipwith c-erbB-2.3). The multivariate analysis of Cox modelof GC showed only DNA ploidy, expression of EGFR,lymph node metastasis and distant metastasis wereindependent prognostic factors of GC.
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