在核糖体上mRNA的拓扑形态、空间取向及其与tRNA的相互作用

摘要

计算机模拟研究显示，在翻译过程中，核糖体上mRNA解折叠后的单链拓扑形态，不仅与mRNA的发夹结构有关，而且与tRNA和mRNA的空间取向和相互作用有关。甚至mRNA链的几何学与新生肽链的几何学之间也可能存在某些相关性。%Computer simulations of ribosome reveal that the geometric features of unfolded single stranded mRNAs are related not only to the spatial orientation and interaction between tRNA and mRNA, but also to the geometric features of mRNA hairpins. There may exist correlation between geometric features of mRNAs and nascent polypeptides.