甲状腺自身抗体、促甲状腺素与早期稽留流产的关系探讨

摘要

ObjectiveTo investigate relationship between thyroid autoantibody, thyroid stimulating hormone (TSH) and early missed abortion.MethodsThere were 126 women with early missed abortion as observation group and 100 normal early pregnancy women as control group. Their thyroid autoantibody and TSH were detected for comparison of detection rates between the two groups.ResultsThe observation group and the control group had total positive rates of thyroid autoantibody as 32.54% and 12.00%, positive rates of thyroid peroxidase antibody (TPOAb) as 25.40% and 8.00%, positive rates of thyroglobulin antibody (TgAb) as 23.02% and 7.00%, and detection rates of TSH ≥2.5 mIU/L as 12.70% and 3.00%. Their differences all had statistical significance (P<0.05). The observation group had higher detection rate of positive thyroid autoantibody (positive TA) and TSH <2.5 mIU/L than the control group, and their difference had statistical significance (P<0.05). There was no statistically significant difference between TSH levels of negative thyroid autoantibody (negative TA) (P>0.05).ConclusionThyroid autoantibody and TSH contain correlation with early missed abortion, and they can be used as predictive factors, while thyroid autoantibody show higher predictive value.%目的：探讨甲状腺自身抗体和促甲状腺激素(TSH)与早期稽留流产的关系。方法选择126例早期稽留流产妇女作为观察组,100例正常早期妊娠妇女作为对照组,常规筛查甲状腺自身抗体和TSH,比较甲状腺自身抗体和TSH 在两组中的检出率。结果在观察组和对照组中,甲状腺自身抗体的总阳性率分别为32.54%和12.00%,抗甲状腺过氧化物酶抗体(TPOAb)阳性率分别为25.40%和8.00%、甲状腺球蛋白抗体(TgAb)阳性率分别为23.02%和7.00%, TSH ≥2.5 mIU/L 的检出率分别为12.70%和3.00%,差异均有统计学意义(P<0.05)；甲状腺自身抗体阳性(TA阳性)且TSH<2.5 mIU/L检出率观察组高于对照组,差异有统计学意义(P<0.05),而甲状腺自身抗体阴性(TA阳性)不论TSH水平高低,两组检出率比较差异均无统计学意义(P>0.05)。结论甲状腺自身抗体和TSH 与早期稽留流产有关,可作为早期稽留流产的预测指标,且甲状腺自身抗体的预测价值更大。