拉呋替丁联合奥美拉唑治疗非甾体抗炎药引起的消化性溃疡的疗效观察

摘要

OBJECTIVE: To observe the efficacy and safety of lafutidine combined with omepazole in the treatment of non-steroidal anti-inflammatory drugs (NSAIDs) peptic ulcer. METHODS: 67 cases of peptic ulcer caused by NSAIDs were randomly divided into 2 groups, there were 34 patients in the treatment group which were received lafutidine and omepazole treatment and 33 cases in the control group which were received omepazole treatment only, both of 2 groups were treated for 4 weeks. Effects and safety of 2 were observed. RESULTS: The clinical efficacy rates of 2 groups were 97.06% and 75.75%, respectively. There were significant differences between 2 groups(P<0.05). There was no serious adverse drug reaction found. CONCLUSION: Lafutidine combined omeprazole is effective in the treatment of peptic ulcer caused by NSAIDs, they were more rapid, high quality of ulcer healing, and good safety.%目的:观察拉呋替丁联合奥美拉唑治疗非甾体抗炎药(NSAIDs)引起的消化性溃疡的疗效与安全性.方法:将67例NSAIDs引起的消化性溃疡患者随机分成2组,治疗组34例,对照组33例.治疗组采用拉呋替丁联合奥美拉唑治疗,对照组单用奥美拉唑治疗,2组疗程均为4周.观察2组治疗效果及安全性.结果:2组患者临床总有效率分别为97.06％和75.75％,治疗组明显优于对照组(P＜0.05).2组均未见严重不良反应发生.结论:拉呋替丁联合奥美拉唑治疗NSAIDs引起的消化性溃疡,作用更迅速,溃疡愈合质量高,安全性较好.