OBJECTIVE: To observe the efficacy and safety of methylcobalamin combined with sdvice mitiorrhgce, liguspyragme hydrochloride and glucose injection for diabetic peripheral neuropathy (DPN). METHODS: 78 patients from May 2010 to Feb 2011 with DPN were randomly assigned into control group and treatment group with 39 cases in each group. Patients in control group were given Methylcobalamin injection 1 mg intravenous drip once a day, and patients in the treatment group were given sdvice mitiorrhgce, liguspyragme hydrochloride and glucose injection 200 Ml once a day for 14 days on the basis of treatment of control group. The treatment of them lasted for 2 courses. The blood glucose level, urine protein, serum creatinine, hemorheology indicators, nerve conductive velocity (NVC) of the tibial nerve and the common peroneal nerve were measured before and after treatment. RESULTS: The clinical efficacy and clinical symptoms improvement of treatment group both were better than those of control group (P<0.05); hemorheology indicators and NVC of the tibial nerve and the common peroneal nerve in treatment group were improved significantly after treatment (P<0.01), while there was no significant change in control group (P>0.05). There was no significant adverse drug reaction found. CONCLUSION: Methylcobalamin combined with sdvice mitiorrhgce, liguspyragme hydrochloride and glucose injection has a synergistic effect on diabetic peripheral neuropathy, which is better than methylcobalamin alone, and has no obvious side effect.%目的:观察甲钴胺联合参芎葡萄糖注射液治疗糖尿病周围神经病变(DPN)的疗效和安全性.方法:将2010年5月-2011年2月收治的DPN患者78例随机均分为2组.对照组单用甲钴胺注射液1 mg,静脉滴注,qd;治疗组在对照组基础上加用参芎葡萄糖注射液200 mL,qd,14d为1个疗程.2组均治疗2个疗程.观察2组治疗前后血糖、尿蛋白、血肌酐、血液流变学指标、患侧腓总神经和胫神经运动传导速度及感觉传导速度等相关指标的变化及不良反应.结果:治疗组临床疗效及症状改善均优于对照组(P＜0.05)；治疗组血液流变学指标、患侧腓总神经和胫神经运动传导速度及感觉传导速度均较治疗前有显著改善(P＜0.01),而对照组较治疗前无明显改善(P＞0.05),治疗后2组比较差异有统计学意义(P＜0.05).2组均未见明显不良反应发生.结论:甲钴胺联合参芎葡萄糖注射液治疗DPN具有协同作用,疗效优于单用甲钴胺治疗,且未见明显副作用.
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