OBJECTIVE:To optimize the extraction technology of Compound Lamiophlomis rotata gel plasters. METHODS:With the yield of extractum,the extract rate and purity(sum of contents of 5 marker components/extract rate)of 5 marker compo-nents (loganin acid,shanzhiside methyl ester,gentiopicroside,8-O-acetyl shanzhiside methyl ester,2′,4′-dihydroxychalcone) as indexes,with ethanol amount,ethanol concentration and extraction time as factors,uniform design (UD) was used to optimize technology parameters. Then dynamic optimization extraction method (DOEM) was employed to further optimize extraction time. RESULTS:The optimum extraction conditions of UD were as follows as 8-fold 90% ethanol,extracting 2 times,1 h each time. The yield of extractum was 24.37%,and the extract rate of 5 marker components were 0.10%,0.51%,1.65%,0.74% and 0.19%,respectively;the purity of them was 13.11%. The extraction time was reduced to 40 times at first time and 30 times at sec-ond time by DOEM;the extract rates of 5 marker components were 0.10%,0.52%,1.78%,0.75% and 0.31%,respectively;the purity of them was 14.08%. CONCLUSIONS:The optimum extraction conditions of UD are reasonable and stable. DOEM can sig-nificantly reduce extraction time,consumption and production costs.%目的：优选复方独一味凝胶贴膏的提取工艺。方法：以浸膏得率、5种指标成分（马钱苷酸、山栀苷甲酯、龙胆苦苷、8-O-乙酰山栀苷甲酯、2′，4′-二羟基查耳酮）提取率和纯度（5种指标成分含量之和/浸膏得率）为评价指标，以乙醇用量、乙醇体积分数、提取时间为考察因素，获得均匀设计优化工艺参数后，进一步采用动态优化法优化提取时间。结果：均匀设计优化工艺为8倍量90％乙醇回流提取2次，每次1 h；优化后的浸膏得率为24.37％，5种指标成分提取率依次为0.10％、0.51％、1.65％、0.74％、0.19％，纯度为13.11％。动态优化后提取时间缩短为第1次40 min、第2次30 min，浸膏得率为24.58％，5种指标成分提取率依次为0.10％、0.52％、1.78％、0.75％、0.31％，纯度为14.08％。结论：均匀设计优选的提取工艺合理、稳定，提取率高；动态优化法可进一步缩短提取时间、降低耗能、节约生产成本。
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