CIN患者HPV感染亚型特点及宫颈锥切术后HPV感染转阴相关因素的研究

摘要

Objective To investigate the subtype features of human papillomavirus (HPV) infection in patients with cer-vical intraepithelial neoplasia (CIN),and analyze the related factors of negative HPV infection after conization. Methods 554 cases of women received two cancer screening in our hospital with positive HPV were selected,the subtype features of HPV infection was retrospectively analyzed,conization was taken to patients with CIN2 and CIN 3 confirmed by pathology,the related factors of negative HPV infection was investigated. Results HPV52,HPV16 and HPV58 were the first three subtypes of infection,was 18.20%,13.05%and 12.5%respectively.HPV negative rate underwent transanal was 76.58%.Univariate analysis showed that age,level of education,parity,severity,involving glands and postoperative anti-inflammatory drugs had no significant correlation with HPV negative.Multivariate analysis showed that postoperative sexual life had significant correlation with HPV negative. Conclusion HPV16 subtypes is the major infections status of patients with CIN.Cervical conization has an obvious efficacy for CIN.Postoperative sexual life maybe the risk factors for HPV negative.%目的：探讨宫颈上皮内瘤变(CIN)患者人类乳头瘤病毒(HPV)感染亚型特点，分析宫颈锥切术后HPV感染转阴的相关因素。方法选择本院接受两癌筛查HPV阳性的544例妇女为研究对象，回顾性分析HPV感染亚型分布特点，经病理确诊的CIN2和CIN3的患者采取宫颈锥切术治疗，探讨术后HPV感染转阴的相关因素。结果前3位感染亚型是HPV52型、HPV16型和HPV58型，分别占18.20%、13.05%和12.5%；宫颈锥切术后半年HPV转阴率为76.58%，单因素分析提示年龄、受教育程度、产次、病变程度、累及腺体和术后应用抗炎药与HPV转阴均无明显相关性，多因素分析提示术后性生活与HPV转阴存在相关性。结论CIN患者以HPV52、HPV16型和HPV58型感染为主，宫颈锥切术治疗CIN效果明显，术后性生活可能是影响HPV感染转阴的相关因素。