布地奈德联合孟鲁司特钠治疗儿童哮喘的临床研究

摘要

目的：布地奈德气雾剂联合孟鲁司特钠咀嚼片在支气管哮喘患儿中的应用效果评价。方法将2013年5月~2014年5月深圳市龙岗区第三人民医院儿科门诊接治的70例轻-中度慢性持续期支气管哮喘患儿按照随机数字表法均分2组，在相同常规治疗及护理基础上：研究组35例患儿给予布地奈德气雾剂及口服孟鲁司特钠咀嚼片联合治疗，对照组35例患儿给予布地奈德气雾剂治疗，对两组患儿治疗1个疗程后的哮喘症状评分及随访期间哮喘控制情况进行综合比较。结果治疗1个疗程后，两组患儿日、夜间哮喘症状评分均有明显下降(P<0.05)；研究组较对照组下降幅度更为显著(P<0.05)；随访期间，研究组哮喘急性发作次数明显少于对照组(P<0.05)；研究组无症状天数比例(87.50%)明显高于对照组(71.43%)(P<0.05)；两组患儿均无严重药物不良反应情况发生。结论在常规治疗基础上给予慢性持续期支气管哮喘患儿布地奈德气雾剂联合孟鲁司特钠咀嚼片治疗可明显减轻患儿哮喘症状，有利于哮喘症状的长期控制，值得临床推广应用。%Objective To evaluate the application effect of inhaled budesonide combined with montelukast sodium chewable tablets in the treatment of children with bronchial asthma. Methods 70 children with mild to moderate chronic persistent bronchial asthma treated in our hospital from May 2013 to May 2014 were selected and randomly di-vided into two groups.35 cases of patients in study group were treated with inhaled budesonide combined with oral montelukast sodium chewable tablets on the bases of the same routine treatment and nursing care while 35 cases of the patients in control group were treated with inhaled budesonide.The asthma symptoms score and the asthma control of the patients between two groups during the follow-up period were compared after one course of drug treatment. Results After one course of treatment,asthma symptom scores in the children between two groups during daytime and night were significantly decreased (P<0.05).Decline in study group was more significant than that in control group (P<0.05).During the follow-up period,the times of acute onset of asthma in study group were significantly less than that in control group (P<0.05).At the same time the rate of symptom free days in study group (87.50%) was significantly higher than 71.43%in control group (P<0.05);There was no serious adverse drug reaction between two groups. Conclusion On the bases of routine treatment,method of inhaled budesonide combined with oral montelukast sodium chewable tablets in the treat-ment of children with chronic persistent bronchial asthma can significantly reduce asthma symptoms and give the long-term control asthma symptoms,which is worthy of clinical application.