冠心病患者中B型钠尿肽与冠状动脉病变程度的相关性研究

摘要

Objective To study the association between plasma brain natriuretic peptide (BNP) and severity of coronary artery vessels in patients with coronary heart disease. Methods 90 patients carrying out coronary angiography diagnosed as coronary heart disease in our hospital from January to December 2013 were selected,and were divided into stable angina pecrotis (SAP) group,unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group.Gensini score was taken according to the result of coronary angiography (CAG).The plasma BNP levels of different groups was mesasured. Results The plasma BNP level of SAP,UAP and AMI group was higher than that of control group (P<0.05);BNP level in AMI group was higher than that of SAP and UAP group,the difference was significant (P<0.01).The level of plasma BNP increasing more,the Gensini score tended to higher (P<0.05).The level of BNP was positively correlated with Gensini score (P<0.01). Conclusion The plasma BNP level can be a good parameter to predict the severity of coronary vessels atheroma.%目的：探讨冠心病患者中B型钠尿肽(BNP)与冠状动脉病变程度的相关性。方法选择2013年1~12月在本院心脏介入中心行冠状动脉造影检查诊断为冠心病的90例患者，将其分为稳定性心绞痛组(SAP)40例、不稳定性心绞痛组(UAP)35例和急性心肌梗死组(AMI)15例，根据造影结果进行Gensini评分，分析不同组别患者的BNP水平。结果SAP、UAP、AMI组BNP水平均较对照组高(P<0.05)；AMI组较UAP、SAP组BNP水平更高，差异有统计学意义(P<0.01)；BNP水平随Gensini积分增加依次增大(P<0.05)，两者呈直线正相关(P<0.01)。结论血浆BNP水平可作为冠心病患者冠状动脉粥样硬化严重程度的预测指标。