Objective To explore the effect of Xinmailong injection on QT dispersion and clinical efficacy in patients with ischemic heart failure.Methods Totally 80 patients with ischemic heart failure in our hospital were selected,and divided into Xinmailong group and control group with 40 cases in each group by random number table.Xinmailong group was given Xinmailong injection based on the conventional heart failure treatment,and control group was given conventional heart failure treatment.The total effective rate of two groups were compared,and left ventricular ejection fraction (LVEF),N terminal brain natriuretic peptide(NT-proBNP),QT dispersion (QTd) of two groups before and after treatment were observed and compared.Results The total effective rate of Xinmailong group was 77.5％ (31/40),and 62.5％ (25/40) in control group,there was significant difference (P ＜ 0.05).LVEF of two groups after treatment [Xinmailong group:(44.3 ± 2.9) ％ ; control group:(40.9 ± 3.1) ％] were higher compared with before treatment (P ＜ 0.05),NT-proBNP of two groups [Xinmailong group:(281± 86) ng/L;control group:(390 ± 93)ng/L] were decreased significantly than before treatment [Xinmailong group:(521 ± 119) ng/L; control group:(509 ± 112) ng/L] (P ＜ 0.05).QTd of Xinmailong group after treatment [(43 ±15)ms] was lower than before treatment [(56 ± 15)ms] (P ＜0.05),but there was no significant difference on QTd in pretherapy and post-treatment [pretherapy:(56 ± 15) ms ; post-treatment:(56 ± 15) ms] (P ＞ 0.05).After treatment,there were significant differences on LVEF,NT-proBNP,QTd between Xinmailong group and control group (P ＜ 0.05).Three cases of Xinmailong group felt dryness of the mouth and nausea after three to five days,and this symptoms alleviated by oneself without any treatment.Conclusions Xinmailong injection can improve myocardial ischemia and reduce the incidence of complex arrhythmias in patients with ischemic heart failure.Moreover,it can increase myocardial contracticity,improve ventricular diastolic function and enhance heart function.%目的 探讨心脉隆对缺血性心脏病心力衰竭患者的临床疗效及QT间期离散度的影响.方法 选择南京鼓楼医院集团仪征医院心内科缺血性心脏病心力衰竭患者80例,应用随机数字表法将其分为心脉隆组和对照组,各40例.心脉隆组在常规抗心力衰竭治疗基础上加用心脉隆注射液,对照组仅应用常规抗心力衰竭治疗.比较2组总有效率,观察并比较2组治疗前后左心室射血分数、N末端脑钠肽原、QT间期离散度的情况.结果 心脉隆组总有效率为77.5％ (31/40),明显高于对照组的62.5％ (25/40),差异有统计学意义(P＜0.05).治疗后,2组左心室射血分数[心脉隆组:(44.3±2.9)％；对照组:(40.9±3.1)％]较治疗前[心脉隆组:(36.8±3.3)％；对照组:(35.6±3.9)％]升高(P＜0.05),N末端脑钠肽原[心脉隆组:(281 ±86)ng/L;对照组:(390±93) ng/L]明显降低[心脉隆组:(521±ll9)ng/L;对照组:(509±112) ng/L](P＜0.05).心脉隆组治疗后QT间期离散度[(43±15) ms]明显低于治疗前[(56±15)ms] (P ＜0.05),而对照组治疗前后QT间期离散度[治疗前:(56±15)ms；治疗后:(56±15) ms]比较差异无统计学意义(P＞0.05).治疗后,心脉隆组的左心室射血分数、N末端脑钠肽原、QT间期离散度与对照组治疗后比较,差异有统计学意义(P＜0.05).心脉隆组3例治疗3～5d后出现口干、恶心症状,未做处理,自行缓解.结论 心脉隆注射液在改善缺血性心脏病心力衰竭患者心肌缺血的同时,还能增强心肌收缩力,改善心室舒张功能,增强心功能.
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