药物流产后加服米非司酮对流产的完全性和阴道流血情况的影响

摘要

Objective To study the effects of drug abortion added with mifepristone to abortioncompleteness and vaginal bleeding. Methods 880 patients received from September2011 to September 2013 period were divided into study group and the control group. All patients took orallymisoprostol, but study group patients took orally mifepristone(50mg) plusly after placentaeejected, compare the abortioneffects and vaginal bleeding. Results The complete abortion rate in study group was higher than in control group(P<0.05), the average vaginal hemorrhage was lower than control group(P < 0.05), curettage rate was lower than control group(x2=4.11,P=0.002). Conclusion Medical abortion plus mifepristone can significantly shorten the bleeding time, extend the effective drug concentrations, promote the decidual eduction, decrease curettage rate, and improve the complete abortion rate. With its simplity, higher feasibility, no pain and cheapity, it is worthy of further clinical practice.%目的：探讨药物流产后加服米非司酮对流产的完全性和阴道流血情况的影响。方法将880例我院妇科门诊于2011年9月~2013年9月期间收治的愿选择药物流产终止妊娠的健康正常早孕妇女分为研究组和对照组，研究组服用米非司酮联合米索前列醇药物流产，胎囊排出后加服米非司酮50mg，对照组行服用米非司酮联合米索前列醇药物流产，胎囊排出后不加服米非司酮，比较两组的流产效果和阴道出血时间。结果研究组完全流产率显著高于对照组（P＜0.05），研究组平均阴道出血时间显著低于对照组（P＜0.01），研究组刮宫率远远低于对照组（x2=4.11，P=0.002）。结论药物流产后加服米非司酮可显著缩短阴道出血时间，延长药物有效浓度，促进蜕膜排出，降低刮宫率，并提高完全流产率。加上服用方法简单，可行性高，患者既可避免机械性清宫对机体造成的伤害和痛苦，又廉价易接受，值得临床进一步探讨实践。