Objective To investigate the clinical efficacy and safety of Xiaoer Yanbian Granules in treatment of upper respiratory tract infection complicated with febrile convulsion. Methods From January 2015 to January 2018, in Yichang First People's Hospital, 238 children with upper respiratory tract infection complicated with febrile convulsion were selected, according to random number table method, they were divided into control group and treatment group, with 119 cases in each group. The control group was treated with conventional therapy, the treatment group was treated with Xiaoer Yanbian Granules on the basis of conventional therapy, the two groups were treated for 3-7 d. The clinical efficacy of the two groups was evaluated and compared, the defervescence time, fading time of coughing, fading time of nasal obstruction and nasal discharge,the fading time of convulsion and the cases of convulsion recurrence in the two groups was recorded and compared, serum level of neuron-specific enolase (NSE) and S-100β protein were measured and compared between the two groups before and after treatment. The adverse reactions in the two groups were recorded and compared. Results The total effective rate of the treatment group was higher than the control group, the difference was statistically significant (P ＜ 0.05). The defervescence time, the fading time of coughing, the fading time of nasal obstruction and nasal discharge, fading time of convulsion and the cases of convulsion recurrence in the treatment group were significantly less than the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the serum NSE, S-100β level of the two groups were significantly lower than before treatment, and these in the treatment group were significantly lower than the control group, the differences were statistically significant (P ＜ 0.05). During the treatment, the incidence of adverse reactions in the treatment group was higher than the control group, but the difference was not statistically significant (P ＞ 0.05). Conclusion Xiaoer Yanbian Granules is effective in the treatment of upper respiratory tract infection complicated with febrile convulsion. It can shorten the duration of clinical symptoms and improve the brain injury of children, it is safe and worthy of clinical application.%目的 探讨小儿咽扁颗粒治疗上呼吸道感染伴热性惊厥的临床效果及安全性.方法 选择2015年1月～2018年1月宜昌市第一人民医院收治的238例上呼吸道感染伴热性惊厥患儿,按随机数字表法分为对照组和治疗组,每组各119例.对照组给予常规治疗,治疗组在常规治疗的基础上联合给予小儿咽扁颗粒治疗,两组均连续治疗3～7 d.评价并比较两组临床疗效.记录并比较两组的退热时间、咳嗽消失时间、鼻塞流涕消失时间、惊厥消失时间及惊厥再次发作例数.检测并比较两组治疗前后血清神经元特异性烯醇化酶(NSE)、S-100β蛋白(S-100β)水平.记录并比较两组治疗过程中不良反应的发生情况.结果 治疗组的总有效率高于对照组,差异有统计学意义(P ＜ 0.05).治疗组的退热时间、咳嗽消失时间、鼻塞流涕消失时间、惊厥消失时间及惊厥再次发作例数均明显小于对照组,差异有统计学意义(P ＜ 0.05).两组治疗后血清NSE、S-100β水平均明显低于治疗前,且治疗组低于对照组,差异有统计学意义(P ＜ 0.05).治疗过程中,治疗组的不良反应发生率稍高于对照组,差异无统计学意义(P ＞ 0.05).结论 小儿咽扁颗粒治疗上呼吸道感染伴热性惊厥的临床效果显著,能够明显缩短临床症状的持续时间,改善患儿脑损伤,且安全性较好,值得在临床上推广应用.
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