2型糖尿病早期血管内皮功能改变的临床研究

摘要

Objective: To investigate the alteration and influence factors of vascular endothelial dysfunction in patients at the early stage of type 2 diabetes mellitus. Methods: 45 T2DM patients without complications (T2DM group) and 38 normal subjects (normal control group, NC group) were recruited. General condition, lipid profiles, glycometabolism parameters, other serum biochemical parameters and SVCAM -1 of two groups were detected. Results: CD The SVCAM -1 levels in T2DM group were significantly higher than that of the NC group [(47.51 ±13.84)mmol/L vs (27.99± 11.66)mmol/L, P<0.01]. ?Positive correlations between the serum SVCAM-1 of the two groups level and BMI(r=0.432, P<0.01), DBP(r=0.229, P< 0.05), FPG(r=0.409, P<0.01), TG(r=0.226, P<0.05), TC(r=0.237, P<0.05) and LDL-C(r=0.241, P<0.05) were showed by variable correlations. There was a negative correlation between the serum SVCAM-1 level and HDL-C(r=-0.259, P<0.01). Conclusion: There are endothelial dysfunction in the early stage of type 2 diabetes mellitus.%目的:探讨2型糖尿病(T2DM)早期患者血管内皮功能的变化及影响因素.方法:选取45例新诊断无并发症的T2DM患者(T2DM组),另设正常对照组38例(NC组),比较两组的一般情况、血脂、糖代谢等生化指标和可溶性血管细胞黏附分子1(SVCAM-1)的差异.结果:①T2DM组SVCAM-1高于NC组[(47.51±13.84)mmol/L vs(27.99±11.66)mmol/L],差异有高度统计学意义(P<0.01).②相关分析显示,血清SVCAM-1与体重指数(BMI,r=0.432,P<0.01)、舒张压(DBP,r=0.229,P<0.05)、空腹血糖(FPG,r=0.409,P<0.01)、三酰甘油(TG,r=0.226,P<0.05)、总胆固醇(TC,r=0.237,P<0.05)、低密度脂蛋白胆固醇(LDL-C,r=0.241,P<0.05)呈显著正相关,与高密度脂蛋白胆固醇(HDL-C,r=-0.259,P<0.01)呈显著负相关.结论:T2DM早期患者即存在血管内皮功能损伤.