夫妇体内重金属含量及环境因素与胎停育的相关性研究

摘要

Objective: To explore the relationship of heavy metal content in couples and production and living environmen -tal factors exposure with embryonic diapause in early pregnancy. Methods: Case-control study was used to analyze the difference of heavy metal contents and the production and living environmental factors between the embryonic diapause cou ples (observation group) and the corresponding normal pregnancy couples (control group). The difference of the blood heavy metal contents between the two groups was statistical by rank sum test. Environmental factors analysis were statistical by the two classification of non-conditional logistic regression, the risk factors correlation with embryonic diapause were screened out. Results: The blood heavy metal element contents of two groups were in normal range, two groups was statis -tical by rank sum test, the difference had no statistically significant (P>0.05). In the condition of the age of two groups had no statistical difference, home decoration or furniture purchase within one year, sickness and taking medicine in early preg -nancy, father smoking and passive smoking in half a year before pregnancy were the risk factors of embryonic diapause (OR>1), couples who had medical examination and medical consultation in half a year before pregnancy was protected factor (OR<1). Conclusion: The environment in Huangdao district is not polluted by heavy metal and can not cause embryonic diapause. According to the result of environment investigation, strengthening the pre-pregnancy medicinal publicity and e -ducation, controlling and reducing the exposure of couple's production and living environment risk factors are particularly important to reduce the risk of embryonic diapause.%目的:探讨胎停育的发生与夫妇体内重金属含量及生产、生活环境因素暴露的关系.方法:采用病例对照方法研究胎停育夫妇(观察组)和同期正常妊娠夫妇(对照组)体内重金属含量及生产、生活环境因素的差异性,对两组夫妇血重金属元素含量检测值采用秩和检验,环境因素分析采用分类数据统计中的二分类非条件logistic回归,筛选出与胎停育相关的可能危险因素.结果:两组夫妇血重金属元素含量检测值均在正常范围,经秩和检验,差异无统计学意义(P>0.05).在两组夫妇在年龄无明显差别的情况下,1年内居室装修或购买家具、孕早期患病服药、父孕前半年吸烟或被动吸烟是发生胎停育的危险因素(均OR值＞1),而夫妇孕前半年内接受医学检查和医学咨询是胎停育发生的保护性因素(OR值<1).结论:黄岛区内环境没有受到重金属污染而导致胎停育,从环境因素调查分析,应加强孕前宣传教育,控制和减少夫妇双方生产、生活环境中的危险因素暴露,对减少胎停育的发生风险尤为重要.