曲唑酮治疗失眠症52例疗效分析

摘要

目的:探讨曲唑酮治疗失眠症的临床疗效和不良反应.方法:用曲唑酮治疗52例失眠症患者,每晚睡前顿服曲唑酮25～150 mg/d,治疗4周后采用PSQI和TESS量表评定其疗效和安全性.结果:治疗后总有效率为88.46%,PSQI评分明显低于疗前(P＜0.05),而治疗第2周TESS明显降低(P＜0.05),第3、4周末TESS与第2周末比较,差异无统计学意义(P＞0.05).曲唑酮的不良反应主要有轻至中度的头昏、困倦等.结论:曲唑酮用于治疗失眠症疗效肯定,副作用少,值得进一步研究和推广.%Objective: To observe the efficiency and security of Trazodone in treatment of the insomnia. Methods: 52 patients with the insomnia were were treated with Trazodone, 25-150 mg every evening for 4 weeks. The clinical efficacy and side-effects were assessed with PSQI and TESS. Results: After treatment, the total effective rate was 88.46％. The PSQI factorial scores were lower than before (P＜0.05),the TESS decreased in the second week of treatment (P＜0.05), the TESS of the third and forth week of treatment had no difference with the sceond week (P＜0.05). The adverse reactions of Trazodone was mild, for example dizziness, drowsiness, et al. Conclusion: Trazodone is effective in treatment of the insomnia and the side effects was fewer and it is worthy of clinical application.