131I治疗对Graves眼病的效果及对细胞因子的影响

摘要

目的 探讨131I治疗对Graves眼病(GO)的效果及对细胞因子的影响.方法 将100例GO患者进行131I治疗后观察GO的变化,并检测IL-6、IL-8、IL-10水平.结果 GO治愈占32%,改善占50%,无变化占13%,加重占5%,131I治疗后IL-6、IL-8、IL10水平比治疗前明显下降.结论 131I治疗能抑制GO患者自身免疫,对GO安全有效.%Objective To study the influence of Graves ophthalmopathy (GO) and cytokine treated with Iodine-131 (131I). Methods 100 patients with GO after treated with 131I to observe GO changes and IL-6, IL-8, IL-10 levels were detected. Results GO cure rate was 32%, improvement was 50%, no change was 13%, increased was 5%, after treated with 131I, IL-6, IL-8. IL-10 levels decreased significantly compared with before treatment. Conclusion 131I therapy can effectively suppress the autoimmunity of patients with GO and is safe to GO.