Prostate cancer is one of the common malignant tumor of elderly men, there is still no satisfactory method for the differential diagnosis, disease progression and prognostic judgment of prostate cancer. In recent years, prostate cancer gene 3 (PCA3) may be the most promising specific markers for prostate cancer in clinical studies, its predictive effect has been confirmed widely in biopsy, it can help to improve prostate cancer diagnosed rate in conjunction with other diagnostic methods and is expected to have special role in predicting tumor aggressiveness and gene therapy. This essay summarizes the research on prediction function in the first time, repeat biopsy of PC A3, PC A3 score's relationship with prostate volume and Gleason grade, PCA3's prediction in the effect of prostate cancer combined with other inspection method, targeted gene therapy effect.%前列腺癌是老年男性常见的恶性肿瘤之一,目前仍无满意的预测方法.前列腺癌基因3(PCA3)可能是最有前景的前列腺癌高特异性标记物,在穿刺活检中的预测作用被广泛证实,在联合其他诊断方法时有助于提高前列腺癌的诊出率,并且有望在预测肿瘤侵略性、基因靶向治疗方面有特殊作用.本文就PCA3基因在初次、重复穿刺活检中的预测作用、PCA3分数与前列腺癌体积和Gleason分级的关系、PCA3联合其他检查方法预测前列腺癌的效果及靶向基因治疗作用等方面进行综述.
展开▼
