胃癌术后患者行中药联合化疗的Meta分析

摘要

目的 通过Meta分析的方法对胃癌术后患者行中药联合化疗的疗效进行评价.方法 检索中国生物医学文献服务系统(SinoMed)、中国知网数据库(CNKI)及万方数据库2002年1月-2012年11月公开发表的所有胃癌术后行中药联合化疗的随机临床对照研究.依照入选和排除标准,最终纳入15篇随机对照试验研究,观察指标包括:恶心呕吐发生率、白细胞减少发生率、1年生存率、3年生存率.应用RevMan5.0软件进行Meta分析.结果 中药联合化疗组白细胞减少及恶心呕吐等化疗不良反应发生率明显低于单纯化疗组,中药联合化疗组1、3年生存率明显高于单纯化疗组,差异均有高度统计学意义(P＜0.01).结论 胃癌术后患者行中药联合化疗能减少化疗的不良反应,延长生存期,优于单纯化疗.%Objective To evaluate the effect of traditional Chinese medicine combined with chemotherapy in postoperative patients with gastric cancer by the Meta-analysis method.Methods The published papers of postoperative gastric cancer patients treated by traditional Chinese medicine combined with chemotherapy in SinoMed, CNKI and Wanfang Data from January 2002 to November 2012 were searched.15 articles were eventually brought into the randomized controlled trial according to the inclusion and exclusion criteria.Nausea vomiting incidence, white blood cells reduce incidence, 1 year survival rate and 3 years survival rate were observed; Meta analysis was carried out by Rev Man 5.0 software.Results Nausea vomiting incidence and white blood cells reduce incidence in traditional Chinese medicine combined with chemotherapy group were all lower than those in pure chemotherapy group, 1 year survival rate and 3 years survival rate in traditional Chinese medicine combined with chemotherapy group were higher than those in pure chemotherapy group, the differences were statistically significant (P < 0.01).Conclusion traditional Chinese medicine combined with chemotherapy in postoperative patients with gastric cancer can reduce the adverse effects of chemotherapy, prolong survival time, so it is better than chemotherapy alone.