应用快速加温透析配液设备对超敏C反应蛋白的影响

摘要

目的：探讨快速加温透析配液对维持性血液透析(MHD)患者超敏C反应蛋白(hs-CRP)的影响。方法：选取长期MHD患者34例，对其进行MHD自身对照观察，并将其分为两组，在2010年冬季使用传统配液法为MHD2010组；2011年冬季使用快速加温透析配液法为MHD2011组。同时抽取30名健康体检者为对照组。对三个组随访3个月，分别比较三组在0月、3个月测定的血清hs-CRP水平。结果：①与对照组相比，MHD2010组及MHD2011组的hs-CRP水平明显升高，差异有统计学意义(t=3.345，P＜0.05)；②随访3个月后MHD2011组和MHD2010组hs-CRP水平与自身治疗前比较都有所下降，差异有统计学意义(分别t=3.346，t=3.356，P＜0.05)；③治疗后， MHD2011组和MHD2010组hs-CRP水平相比较，差别无统计学意义(t=1.019，P＞0.05)。结论：MHD患者存在微炎症状态，与传统配液法相比，快速加温透析配液法也可降低hs-CRP水平。%Objective: To investigate the influence of fast heating-up dialysate dispensing equipment on high sensitivity C reactive protein of maintenance hemodialysis. Methods:We firstly got thirty health people population(12 males and 18 females, mean age 46.18±16.35), thirty-four patients with maintenance hemodialysis(20 males and 14 females, mean age 50.39±14.48). While MHD thirty-four patients were conducted by self-controlled trial, respectively in the winter of 2010 using conventional method (MHD2010 group), 2011 for fast heating-up dialysate dispensing equipment method (MHD2011 group), followed up for 3 months, compared serum hs-CRP levels of three groups of 0 month, third month. Results: (1)Compared with the healthy group, hs-CRP levels of MHD2010 group and MHD2011 group were significantly increased, the difference was statistically significant(t=3.345, P<0.05). (2)Followed-up for three months, hs-CRP levels of MHD2011 group and MHD2010 group were declined, the difference was statistically significant(t=3.346, P<0.05). (3)After treatment, the hs-CRP levels of MHD2011 group and MHD2010 group compared, The difference was not statistically significant (t=1.019, P>0.05). Conclusion:Micro-inflammatory state, exists in patients with maintenance hemodialysis, fast heating-up dialysate dispensing equipment could reduce the levels of hs-CRP, the same to conventional method.