Objective: To analyze the application value of transient elastic wave monitoring in the development of chronic hepatitis. Methods: 127 cases of chronic hepatitis patients with liver fibrosis were divided into the four groups, including S1 fibrosis group (30 cases), S2 hepatic fibrosis group (35 cases), S3 liver fibrosis group (32 cases) and S4 group (30 cases). And using diagnostic apparatus measured liver stiffness values in the four groups. According to the FS values of different stages of liver fibrosis, the receiver operating characteristic curve, and the area under the curve and the specificity and sensitivity of the diagnosis were calculated. Results:The differences of FS values in different fibrosis stages (FS) were statistically significant (F=1597.89, P<0.05). The areas of the S1 fibrosis group, S2 fibrosis group, S3 liver fibrosis and S4 cirrhosis were 0.766, 0.862, 0.891 and 0.805. The diagnostic values were 10.0, 10.7, 11.9 and 15.2 kPa. The sensitivities were 75.4, 76.8, 85.3 and 75.2, and the specificities were 80.5, 69.9, 66.2 and 76.8. Conclusion: Transient elastic wave monitoring has a high diagnostic specificity and sensitivity for the diagnosis of liver cirrhosis.%目的：评价瞬时弹性波监测仪在慢性乙型肝炎疾病进展中的应用价值。方法：选取127例慢性乙型肝炎肝纤维化患者，根据肝脏的病理分期，按照纤维化程度不同将其分为肝纤维化S1期组(30例)、S2期组(35例)、S3期组(32例)及S4期组(30例)，分别采用Fibroscan诊断仪测量4组患者的肝脏硬度(FS)值，同时绘制4组患者FS值的受试者工作特征曲线，计算曲线下面积和诊断的特异度及灵敏性。结果：Fibroscan 诊断仪测量4组患者的FS值差异有统计学意义(F=1597.89，P＜0.05)，且以S4期组患者的FS值最高。S1期组，S2期组、S3期组和S4期组的曲线下面积分别为0.766、0.862、0.891和0.805，诊断的界值分别为10.0 kPa、10.7 kPa、11.9 kPa和15.2 kPa，灵敏度分别为75.4%、76.8%、85.3%及75.2%，特异度分别为80.5%、69.9%、66.2%及76.8%。结论：瞬时弹性波监测在慢性乙型肝炎疾病肝硬化分期和评估慢性乙型肝炎疾病进展中的诊断特异性和灵敏度均较高，且检查手段无创。
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