基于柠檬酸的生物可降解高分子材料的设计、开发及应用

摘要

生物材料在生物医学工程,尤其是组织工程、药物控释、植入物和医疗器械中发挥着越来越重要的作用.尤其是生物可降解材料,降解性能保证了材料在发挥应有的功能后不在体内残留.而生物可降解弹性体,基于其优异的力学性能,可用于支持软组织的修复与再生.近年来,作者所在研究小组开发了基于柠檬酸的一系列生物可降解弹性体(CABEs),并应用于血管、软骨、皮肤、骨科等组织工程领域及药物控释、生物影像和伤口粘合等领域.基于柠檬酸的生物可降解聚合物在未来有潜在的临床应用价值.%Biological materials play an increasingly important role in biomedical engineering, especially in tissue engineering, drug delivery, implants and medical devices. Biodegradable materials ensure that no residue exists in the body. Biodegradable elastomer, based on its excellent mechanical properties, can be used to support the repair and regeneration of soft tissue. In recent years, our research team has developed a series of biological citric acid-based biodegradable elastomers (CABEs), which are applied to tissue engineering, drug delivery, biological imaging and wound adhesive, etc. Citric acid-based biological degradable polymers have potential clinical value in the future.