家兔腹部注射生理盐水的磁感应r断层成像在体检测研究

摘要

目的 研究磁感应断层成像技术对活体动物体内电阻抗改变在体检测的可行性.方法 建立家兔腹部注射生理盐水模型.使用自研的16通道磁感应断层成像实验系统进行检测,通过时间差分Newton-Raphson成像算法获得相对注射前状态的电导率分布变化量的重建图像.对重建值与注射剂量的关系进行线性回归分析和统计学差异分析.结果 重建图像显示出生理盐水的注射位置,其对应重建值随注射剂量的增加而上升,与剂量呈线性相关.结论 磁感应断层成像技术可以在体检测活体动物体内的电导率分布变化情况,并能正确反映目标位置及重建值与注射剂量的变化趋势.%Objective Our study aimed to investigate the feasibility of magnetic induction tomography (MIT) detecting the conductivity distributionin vivo.Methods A model of injecting normal saline into rabbit's abdomen was established. The time-difference Newton-Raphson algorithm was applied to obtain the reconstructed images based on the background frames of conductivity distribution before injection by a 16 excitation-detection multiplex coils system. Statistical correlation and the significant differences between reconstructed values and doses were subsequently analyzed.Results The reconstructed images showed the position of the saline injection, whose reconstructed values up-regulated with the dose increasing and were linearly dependent with dose.Conclusion MIT is available to investigate conductivity distributionin vivo by detecting the position and the variation trend of reconstructed values exactly with injected dose.