抗胸腺细胞球蛋白治疗肾移植术后早期耐激素的排斥反应

摘要

目的:观察抗胸腺细胞球蛋白(ATG)治疗肾移植术后早期耐激素排斥反应的效果.方法:对34例尸体肾移植术后3d内应用激素冲击治疗期间发生排斥反应的患者以及术后3d后发生耐激素排斥反应的患者采用ATG治疗.结果:其中32例排斥反应得以逆转,肾功能恢复正常,其治愈率为94.1%.2例虽然控制排斥反应,但其肾功能未能恢复,未行移植肾切除.结论:抗胸腺细胞球蛋白(ATG)治疗早期耐激素排斥反应的效果显著,可以使有耐激素排斥反应的肾移植患者获得良好的肾功能.%Objective:To observe the effect of antithymocyte globulin(ATG) on early steroid-resistant rejcctions after kidney transplantation.Methods:34 steroid-resistant patients were treated with ATG who had rejetion during hormone impact treatment within 3 days after transplantation or resistant response 3 days after kidney transplantation.Results:In 32 of 34 steroid-resistant patients after kidney transplantation, their rejections were reversed and their renal function recovered with curing rate of 94.1%.In 2 of 43 cases, their rejections were controlled, but their renal function did not recover.Conclusions:ATG was a potent immunosuppresant capable of reversing early steroid-resistant rejections. Patients with steroid-ressitant rejectons after transplantation could get favorable renal function.