血清胱抑素C在糖尿病肾病早期诊断中的诊断价值

摘要

Objective To investigate the serum cystatin C(CysC)diagnostic value in early diagnosis of diabetic nephropathy.MethodsSelected 150 cases of diabetic patients,according to urinary albumin excretion rate(UAER)were be divided into 3 groups,namely normal albuminuria group,microalbuminuria group and clinical proteinuria group,80 healthy persons were selected as control group. The level of detection of all research objects CysC,BUN,Scr and Ccr.ResultsThe normal albuminuria group serum CysC compared with the control group,the difference was statistically significant(P<0.05),normal albuminuria group Scr,BUN,Ccr and the control group,the difference was not statistically significant (P>0.05),comparison of microalbuminuria group,clinical albuminuria group and control group CysC,BUN,Scr and Ccr,the differences were statistically significant(P<0.05).Conclusion Serum CysC is an ideal biochemical index in the early diagnosis of diabetic nephropathy,and it can be used to evaluate renal function damage with Ccr,Scr and BUN.%目的：探讨血清胱抑素C（CysC）在糖尿病肾病早期诊断中的诊断价值。方法收集我院150例糖尿病患者，根据尿清蛋白排泄率（UAER）将其分为3组，即正常蛋白尿组、微量蛋白尿组及临床蛋白尿组；选取80例健康体检者组成对照组，检测所有研究对象的CysC、BUN、Scr及Ccr的水平。结果正常蛋白尿组血清CysC和对照组比较，差异有统计学意义（P＜0.05），正常蛋白尿组Scr、BUN、Ccr和对照组比较，差异无统计学意义（P＞0.05），微量蛋白尿组、临床蛋白尿组和对照组的CysC、BUN、Scr、Ccr比较，差异均有统计学意义（P＜0.05）。结论血清CysC是糖尿病肾病早期诊断的理想生化指标，可以和BUN、Scr及Ccr一起用于评估肾功能损伤。