帕金森病伴发轻度认知障碍患者血浆磷脂分子含量变化及意义

摘要

目的：分析探讨帕金森病伴发轻度认知障碍患者血浆磷脂分子含量变化和意义。方法选择2012年3月-2014年3月该院治疗的帕金森病伴发轻度认知障碍患者50例，并选择同期在该院健康体检的50例和帕金森病无认知障碍的50例分别作为对照组A和对照组月，测定三组研究对象的血浆磷脂含量，并评定研究对象的智能状态，分析研究对象智能状态与血浆磷脂含量之间的关系。结果观察组MMSE得分、CDT得分以及MoCA得分均明显低于对照组A和对照组月(P<0.01)；观察组的磷脂分子含量明显高于对照组A和对照组B(P<0.01)；两组之间各项指标差异无统计学意义(P>0.05)。结论帕金森病伴发轻度认知障碍患者细胞膜受到了严重的损伤，血浆磷脂分子可作为新生物标记物，通过其含量变化可判断认知功能受损情况。%Objective Analysis and Discussion of Parkinson's disease in patients with mild cognitive impairment associated with plasma phospholipid molecules content and significance. Methods March 2012 to March 2014 in our hospital associated with the treatment of Parkinson's disease in 50 patients with mild cognitive impairment, and healthy choice the same period in the hospital and 50 cases of Parkinson's disease without cognitive impairment 50 cases were used as the control group a and group B, plasma phospholipid content of the three groups of study and assess the state of the research object of intelligence, analysis of the rela-tionship between the state and the smart object between plasma phospholipid content. Results Observation group MMSE score, CDT score and MoCA scores were significantly lower than the control group A and group B (P<0.01); the content of phospholipid molecules in the observation group was significantly higher in the control group A and B (P<0.01);two the indicators were not sig-nificantly different between the control group (P>0.05). Conclusion The cell membrane of PD-MCI patients suffered serious dam-age; plasma phospholipid molecules can be used as a new biomarker, through its content changes can determine the cognitive function damage.