Objective To analyze the clinical effects of docetaxel and oxaliplatin and fluorouracil in the treatment of ad-vanced gastric cancer. Methods Random selection the inclusion criteria in March 2015-March 2016 into my hospital 60 patients with advanced gastric cancer patients were randomly divided into experimental group and control group, 30 patients in the control group were treated with docetaxel combined with fluoropyrimidine treatment The experimental group received oxaliplatin combined with fluoropyrimidine treatment were compared short-term effect, long-term efficacy and toxicity. Re-sults The two groups differences in short-term and long-term curative effect is not significant, no statistical significance(P>0.05), control group of white blood cells decreased the total incidence rate was 86.67% was significantly higher than that of the experimental group was 66.67%, and the experimental group Zhou neurotoxins occur rate is 66.67% was significantly higher than that of the control group 31.17%, difference has statistical significance (P< 0.05). Conclusion Docetaxel and oxaliplatin combined with fluorouracil drug in the treatment of advanced gastric cancer has the characteristics of clinical application of different and need personalized selection according to the actual situation of patients.%目的：分析多西他赛与奥沙利铂联合氟尿嘧啶类药物治疗晚期胃癌的临床效果。方法随机选取符合纳入标准2015年3月-2016年3月期间进入该院的60例晚期胃癌患者随机分为实验组和对照组，每组30例，对照组采用多西他赛联合氟尿嘧啶类药物治疗方式，实验组采用奥沙利铂联合氟尿嘧啶类药物治疗方式，比较两组近期疗效、远期疗效和不良反应。结果两组在近期疗效和远期疗效方面差异无统计学意义(P>0.05)，对照组白细胞减少总发生率为86.67%明显高于实验组66.67%，而实验组外周神经毒素发生率66.67%明显高于对照组31.17%，差异有统计学意义(P<0.05)。结论多西他赛与奥沙利铂联合氟尿嘧啶类药物治疗晚期胃癌具有不同的临床应用特点，需要根据患者实际情况进行个性化选择。
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