Objective To analyze and explore the effect of aspirin and clopidogrel in treatment of myocardial infarction on the case fatality rate of patients. Methods 60 cases of patients with myocardial infarction diagnosed in the out-patient de-partment of our hospital from April 2012 to August 2015 were collected for clinical research and randomly and double-blindly divided into two groups with 30 cases in each, the control group were treated with single aspirin, the experimental group were treated with aspirin and clopidogrel, and the clinical curative effects of the two groups were observed and the case fatality rates of patients were observed through follow-up. Results After treatment, 17 cases were markedly effective (56.67%), 11 cases were effective (36.67%), 2 cases were ineffective (6.67%) and the total effective rate was 93.33% in the experimental group; 13 cases were markedly effective (43.33%), 9 cases were effective (30.00%), 8 cases were ineffective (26.67%) and the total effective rate was 73.33% in the control group, the total effective rate in the experimental group was obviously higher than that in the control group, and the differences between groups were obvious with statistical signifi-cance, P<0.05, the postoperative follow-up results showed that 5 cases died in total after 1-year treatment and the case fa-tality rate was 16.67%in the experimental group and 12 cases died in total after 1-year treatment and the case fatality rate was 40.0%, and the comparisons had statistical significance between the two groups, P<0.05. Conclusion The curative ef-fect of aspirin and clopidogrel in treatment of patients with myocardial infarction is obvious, which can effectively reduce the case fatality rate of patients, and it is worth further clinical promotion.%目的：分析及探索对心肌梗死(MI)患者采用阿司匹林与氯吡格雷联合治疗对其病死率的影响。方法方便收集该院2012年4月—2015年8月门诊部接诊的MI患者60例进行临床研究，按照随机、对照、双盲的原则将其随机分成实验组(30例)与对照组(30例)。对照组单纯给予阿司匹林治疗，实验组则采用阿司匹林与氯吡格雷联合治疗。观察两组患者的临床疗效，并通过随访观察患者的病死率。结果治疗后，实验组显效为17例(56.67%)，有效为11例(36.67%)，无效为2例(6.67%)，总有效率为93.33%；对照组显效为13例(43.33%)，有效为9例(30.00%)，无效为8例(26.67%)，总有效率为73.33%，实验组患者的总有效率明显高于对照组患者，组间数据差异有统计学意义(P﹤0.05)。术后随访结果显示，实验组患者治疗后1年内共有5例患者死亡，病死率为(16.67%)；对照组患者治疗后1年内共有12例患者死亡，病死率为(40.0%)，两组对比差异有统计学意义(P﹤0.05)。结论对MI患者采用阿司匹林与氯吡格雷联合方案治疗疗效显著，可有效降低患者的病死率，值得临床进一步推广。
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