Formation of Stable Lamellar Gel Structure Containing Pseudoceramide and Its Evaluation of Barrier Recovery Function

摘要

cqvip:This study is focused on the observation of high concentration pseudo-ceramide lamella gel structures' physical property and skin barrier recovery. Consistency of this lamellar gel creams were checked for 1 month on various temperatures and for 1 year on RT. Generally, multi-lamellar emulsion shows typical Maltese cross on polarized microscope, but Maltese cross was not found in case of these creams; Multi-lamellar structure of the creams could be identified by small-angle X-ray scattering(SAXS). To evaluate skin barrier recovery function,we applied one of this creams and a vehicle cream to forearm skin which is tape-stripped to remove barrier layer to see if they influence mass of molecules related to barrier function. 96 h after application, we found that this lamellar gel cream promoted synthesis of ceramides, amino acids and NMFs, thereby enhanced barrier recovery function.