目的：分析万古霉素联合替考拉宁治疗重症革兰氏阳性菌感染的临床效果及评价。方法搜集本院2014年1月～2015年1月收治的46例革兰氏阳性菌感染的重症患者，随机分为两组，21例对照组给予单纯万古霉素药物，25例研究组给予万古霉素与替考拉宁联合药物，对比两组疗效。结果两组疗效比较，研究组治疗总有效率为92.0%、细菌清除率为88.0%、不良反应的发生率为8%优于对照组81.0%、71.4%、23.8%，P＜0.05,差异具有统计学意义。结论万古霉素联合替考拉宁治疗重症革兰氏阳性菌感染的疗效显著，患者的治疗效果好，细菌感染清除率高、用药安全性也高，临床应用价值极高。%Objective Clinical effect and evaluation on Vancomycin combine with Teicoplanin medication in treatment of severe Gram-positive bacteria infection. Methods Selected 46 patients infected with severe Gram-positive bacteria that were treated in hospital from January 2014 to January 2015 and separate them into two groups at random, 21 patients in control group were given Vancomycin medication treatment only, while 25 patients in study group were given Vancomycin combined with Teicoplanin medication treatment and then compared treatment effects between two groups. Results Patients’ treatment efficacy in study group was 92.0%, bacteria cleansing rate was up to 88.0% and side-effect incidence was 8%, which are much better than counterparts of 81.0%, 71.4%and 23.8%in control, P<0.05,had difference statistically significance. Conclusion Vancomycin combined with Teicoplanin medication is of efficacy in treatment of severe Gram-positive bacteria infection; it is conducive to increasing bacteria cleansing rate with medication safety, thus, such a medication treatment is of great application value.
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