妊娠合并甲状腺功能减退症的患病率、妊娠合并症、妊娠结局及对新生儿的影响

摘要

目的：分析妊娠合并甲状腺功能减退症的患病率、妊娠合并症、妊娠结局及对新生儿的影响。方法回顾性分析80例妊娠合并甲状腺功能减退症患者的临床资料，按照患者妊娠终止前的外周血促甲状腺素（TSH）水平，将80例患者分成控制组（TSH＜3.0 mIU/L）53例、未控制组（TSH≥3.0 mIU/L）27例；并选择同期甲状腺功能正常的分娩者50例作为对照组。结果妊娠合并甲状腺功能减退症的发病率逐年增加；在胎膜早破、早产、胎儿宫内受限、胎儿畸形发生率方面，未控制组和控制组、对照组比较差异有统计学意义（P＜0.05）。结论对妊娠合并甲状腺功能减退症的患者，及时发现并给予针对性的治疗，能对妊娠结局进行有效改善。%Objective To analyze the prevalence of pregnancy with hypothyroidism, pregnancy complications, pregnancy outcomes and inlfuence on newborns. Methods The clinical data of 80 pregnant women with hypothyroidism were retrospectively analyzed. According to the patients before the termination of pregnancy in peripheral blood thyrotropin (TSH) level, 80 patients were divided into control group (TSH<3.0 mIU/L) in 53 cases, and uncontrolled group (TSH≥3.0 mIU/L) in 27 cases. And 50 patients with normal thyroid function were selected as reference group. Results The incidence of hypothyroidism was increasing year by year. In premature rupture of membranes, premature birth, fetal conifnement, fetal malformation rate,there was no signiifcant difference between the control group, uncontrolled group and the reference group (P<0.05). Conclusion For the patients with pregnancy complicated with hypothyroidism, timely detection and targeted treatment can effectively improve the pregnancy outcome.