EFFECTS OF BAICALEIN, WOGONIN, BAICALIN AND Na2MoO_4 ON N-NITROSATION REACTION

摘要

The in vitro effects of baicalein,wogonin,baicalin and Na2MoO4 on N-nitrosation reaction have been studied. The N-nitrosation reaction has been determined by the amount of dimethylnitrosamine（DMN） and diethylnitrosamine（DEN） produced using the UV-photclysis spectrophotometric and pyrolysis gas chromatography test. Baicalein,wogonin and Na2MoO4 showed varing extents of inhibition of the formation of DMN and DEN. Baicalin promoted the formation of DMN and DEN under the condition of simulating gastric Juices. It is also found that E. coli showed a remarkable promoting effect on the formation of DMN and DEN,but this promoting effect could be blocked to some extent by baicalein,wogonin,baicalin and Na2MoO4. Besides, Na2MoO4 and wogonin have shown synergic effect on the blocking of N-nitrosation reaction.