STUDIES ON THE SYNTHESIS OF ISOSARCOPHYTOL-A

摘要

A precursor 9 of isosarcophytol-A(1)was prepared from(■)-farnesol(3)through 6 steps.Isosarcophytol-A(1),a cembrane-type diterpenoid,was first isolated fromustralian soft coral(Nephthea brassica)in 1982,and its structure was estab-shed as(1,3,7,11-all ■,13■)-cembra-1,3,7,11-tetraen-13-ol,an isomer ofarcophytol-A■.As far as we know,its bioactivity and synthesis have noteen reported yet.