Photochemical defluorinative functionalization of α-polyfluorinated carbonyls via spin-center shift

摘要

Organic molecules containing gem–difluoromethylene unit are one of the most important classes of compounds that have various valuable applications ranging from drug discovery to material science [1]. Not surprisingly, numerous strategies have been developed towards the synthesis of these target organofluorine compounds. Within this research area, direct C–F bond cleavage of cheap and readily accessible polyfluorinated compounds represents one of the most potentially powerful methods to access diverse gem–difluoromethylene skeletons.