Stereospecific access to bridgedn.2.1skeletons through gold-catalyzed tandem reaction of indolyl homopropargyl amides

摘要

An efficient gold-catalyzed anti-Markovnikov cycloisomerization-initiated tandem reaction of Bocprotected indole tethered homopropargyl amides has been achieved.This method delivers a wide range of valuable bridged aza-[n.2.1]skeletons(n=3-7)at room temperature with high diastereoselectivity and enantioselectivity by a chirality-transfer strategy.Moreover,the gold-catalyzed tandem reaction of homopropargyl alcohol is also achieved to produce the bridged oxa-[3.2.1]skeleton.