Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var.biloba

摘要

(+)-Magoilgomer A[(±)-1]and magoilgomer B(2)were identified from the bark of Magnolia officinalis var.biloba.(+)-1 and(-)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits.2 was an unprecedented adduct containing magnolol and honokiol.These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits.The structures of(±)-1 and 2 were elucidated based on the spectroscopic data analyses and electronic circular dichroism(ECD)calculations.2 exhibited neuroprotective effects of oxygen glucose deprivation-induced SK-N-SH cell injury.