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>C_2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates
C_2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates
The asymmetric a-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates has been achieved by C2-symmetric BINOL-squaramide bearing multiple hydrogen bond donors to provide the desired products in excellent yields and enantioselectivities(up to 99% yield and 98% ee).
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State Key Laboratory of Virology,Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(Wuhan University),Ministry of Education,Wuhan University School of Pharmaceutical Sciences;