高锰酸钾氧化马鞭草烯酮的研究

摘要

考察了反应温度、反应时间、高锰酸钾用量、乙酸与水溶液体积比对高锰酸钾氧化马鞭草烯酮制备低蒎酮酸的影响,研究结果表明:控制原料与高锰酸钾的物质的量比1∶4,反应温度10℃,反应时间2h,乙酸与水溶液体积比10∶1,得到低蒎酮酸的收率77％.讨论了硅胶作为载体对此实验的影响,结果显示使用硅胶-高锰酸钾作为氧化剂,目标产物的产率可提高到81％.%Effects of reaction temperature, reaction time, potassium permanganate amount and ratio of acetic acid to water on preparation of pinononic aicd by oxidation of verbenone with potassium permanganate were investigated. The results showed that by keeping the molar ratio of (+)-verbenone to potassium permanganate as 1:4, reaction temperature 10℃ , reaction time 2 h and the ratio of acetic acid to water 10: 1, the yield of (+) -pinononic acid reached 77 %. Furthermore, the effect of silica gel as a support on this reaction was also discussed. The results showed that taking silica gel-supported potassium permanganate as oxidant, the yield of the target product could be increased to 81 %.