采用十二烷基硫酸钠(SDS)对壳聚糖(CS)链上的氨基进行保护,得到中间产物壳聚糖-十二烷基硫酸钠复合物(CS-SDS).以六亚甲基二异氰酸酯(HDI)为偶联剂活化聚乙二醇单甲醚(mPEG)得 mPEG-NCO.将 mPEG-NCO接枝到CS-SDS上,脱除壳聚糖氨基保护,制得 CS与 mPEG 的接枝共聚物 CS-g-mPEG,并采用 FTIR、1HNMR、GPC、XRD、TG-DTG等方法对产物结构进行表征.XRD分析表明,CS-g-mPEG结晶度降低,溶解性提高;热重分析表明,CS-g-mPEG降解温度升高,热稳定性提高;CS-g-mPEG的摩尔接枝率达到 28.55%.%We used sodium dodecyl sulfate(SDS)to protect the amino group on chitosan(CS)chain,and ob-tained the intermediate product of chitosan-sodium dodecyl sulfate complex(CS-SDS).Furthermore,using 1,6-hexamethylene diisocyanate(HDI)as a coupling agent,we abtained activated mPEG-NCO,which grafted onto CS-SDS,removed chitosan amino protection,and synthesized graft copolymer CS-g-mPEG.Furthermore,we characterized the structure of the product by FTIR,1HNMR,GPC,XRD,and TG-DTG.XRD analysis results show that crystallinity of CS-g-mPEG decreases,and the solubility improves.Thermogravimetry analysis results show that the degradation temperature of CS-g-mPEG increases,and the thermal stability improves.The molar grafting rate of CS-g-mPEG reaches 28.55%.
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