Ester Bond Containing Protein:Mechanically Stable Yet Dynamic

摘要

Gram-positive pathogens can colonize on mucosal tissues stably withstanding large mechanical disturbance from coughing and sneezing by secreting special surface adhesion proteins.However,how these proteins resist mechanical unfolding remains unknown.In a recent work,using single molecule force spectroscopy,Cao et al.discovered that an ester bond containing surface adhesion protein from Gram-positive bacteria,Clostridium perfringenes.