Studies on the Total Synthesis of Sarcophytol-A——Synthesis of 2-Isopropyl-2-(3-Methyl-1-Benzoxyl-5-Phenylsulfonyl-3E-Pentenyl )-1,3-Dithiocyclohexane

摘要

The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps are nucleophilic addition of 2-1ithio-2-isopropyl-1,3-dithiocyclohexane to aldehyde 5 and double bond migration reaction of allylic alcohol 9 and 10.