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>Diels-Alder Reactions of 6-Hydroxy-2H-pyran-3(6H)-ones with Cyclopentadiene and Its Application for the Synthesis of New Skeletal Oxa-Cage Compounds
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Diels-Alder Reactions of 6-Hydroxy-2H-pyran-3(6H)-ones with Cyclopentadiene and Its Application for the Synthesis of New Skeletal Oxa-Cage Compounds
The 2(5H)-furanone and 3(6H)-pyranone structures are frequently found in natural products, which have a broad range of biological activities. In addition, furanones and pyranones have served as versatile intermediates in the synthesis of a variety of products. 1 Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.2 As part of a program that involves the synthesis, chemistry, and applications of heterocyclic cage compounds, we report here the Diels-Alder reactions of 6-hydroxy2H-pyran-3(6H)-ones 1 and 2 with cyclopentadiene and the application of the cycloadducts for the synthesis of oxa-cage compounds 3-6 with new skeleton. Compound 6 is a potential new chiral amino-alcohol.
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机译:@@ The 2(5H)-furanone and 3(6H)-pyranone structures are frequently found in natural products, which have a broad range of biological activities. In addition, furanones and pyranones have served as versatile intermediates in the synthesis of a variety of products. 1Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.2 As part of a program that involves the synthesis, chemistry, and applications of heterocyclic cage compounds, we report here the Diels-Alder reactions of 6-hydroxy2H-pyran-3(6H)-ones 1 and 2 with cyclopentadiene and the application of the cycloadducts for the synthesis of oxa-cage compounds 3-6 with new skeleton. Compound 6 is a potential new chiral amino-alcohol.
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